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Treatments for Pulmonary Arterial Hypertension (PAH)

Goals of PAH Treatment

• There is no known cure for PAH (pulmonary arterial hypertension).
• Treatments are therapies that reduce symptoms and may even affect the disease process that causes the symptoms.

Multiple options for PAH treatment¹

• PAH Treatments address different:
• Symptoms
• Underlying causes/imbalances
• PAH Treatments offer different
  • Methods of delivery
  • Side effect profiles
• Individual response to therapies may be different.

How does treatment for pulmonary arterial hypertension (PAH) work?^1,2

• PAH Treatments Reduce:
  • Vasoconstriction (tightening of blood vessels)
  • Inflammation (swelling)
  • Cell production
  • Blood clotting
• There are three major therapeutic classes of PAH treatment that address 3 key pathways:
• ERAs (Endothelin Receptor Antagonists) block the chemical endothelin that narrows blood vessels
• Man-made prostacyclins (prostacyclin analogues) stimulate the cells that cause blood vessels to expand
• PDE-5 Inhibitors (phosphodiesterase 5 inhibitors) prevent a chain of events that leads to blood vessel narrowing

Ventavis is approved for the treatment of NYHA Class III or IV pulmonary arterial hypertension (PAH).

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For more information about
Ventavis, please call
1-866-ACTELION (1-866-228-3546).