• Why Take Ventavis?

• Start and Stay on Therapy

• Ventavis FAQs

• Taking Ventavis with the
  I-neb AAD

•      Ventavis Dosing Options

•      
  Setting Up the I-neb AAD

•      Cleaning

• Resources

• For Healthcare
  Professionals

The I-neb is my neb

Learning how to use the I-neb AAD System

Your I-neb AAD System¹

Mobility, freedom, and portability. That's what you get with the I-neb AAD System. You can take the I-neb AAD System with you for treatments almost anywhere at any time.* The I-neb AAD System comes with two convenient carrying cases for your chamber lids with mesh.

What is the I-neb AAD?

The I-neb AAD is a special system that is used to inhale Ventavis. AAD stands for Adaptive Aerosol Delivery. Ventavis must be taken with the I-neb AAD System because it is the only system approved by the FDA and available for use with Ventavis. Ventavis should be inhaled as your doctor prescribes, usually 6-9 times a day, but not more often than every 2 hours.²

Why is Ventavis inhaled?

Inhaling Ventavis gets it right to the lungs—the site of the disease. Inhaled Ventavis therapy allows patients to avoid infections and other complications that may occur with pumps, needles, and catheters—the other ways to deliver manmade prostacyclin into the body.

Designed for your ease of use¹

• No need for difficult assembly or disassembly, as with some nebulizers
• No daily, weekly, or monthly scheduled part replacement
• Only once-a-day cleaning and weekly boil—no daily boiling required

Adapts to your breathing pattern

• Smart technology learns your unique breathing pattern
• Adaptability means you’ll get the right amount of medicine delivered right to your lungs

You can take it with you

• Unlike some nebulizers, the I-neb AAD isn’t big and bulky—you can take your treatments almost anywhere, as prescribed
• Up to 40 uses per battery charge
• Small and lightweight—fits into a purse or jacket pocket

After you receive your Ventavis prescription and I-neb AAD System from your specialty pharmacy, they will schedule a meeting between you and a Ventavis-trained nurse educator. The nurse educator will meet with you (either at home or in your doctor’s office) to show you how to take your Ventavis treatments, and how to use and clean the I-neb AAD System.

• Each treatment should take about 4 to 10 minutes.
• If you notice that your treatments are starting to take longer than usual, call your specialty pharmacy to ask for help.
• Or you can call PAH Pathways^™. Our team of PAH Pathways Counselors will work with your insurance provider to help answer your questions. Call 1-866- ACTELION (1-866-228-3546) Monday through Friday, 9 AM to 8 PM (Eastern time), 6 AM to 5 PM (Pacific time), to help get you back on track.

Read more about the I-neb AAD system:

What is Ventavis?

Ventavis is a prescription medicine used to treat adults with certain kinds of severe pulmonary arterial hypertension (PAH), a condition in which blood pressure is too high in the blood vessels between the heart and the lungs. Ventavis may improve your ability to exercise and your symptoms for a short time by lowering your blood pressure and opening up the blood vessels in your lungs.

• In the key clinical study, Ventavis showed clinical improvement as defined by 3 specific measurements: ability to exercise as measured by the 6-minute walk test, symptoms (NYHA Functional Class), and decrease in the worsening of PAH symptoms.
• Ventavis is a medication you breathe in through a special device called the I-neb Adaptive Aerosol Delivery (AAD) System.

The study showing Ventavis is effective included mainly patients with NYHA Functional Class III-IV PAH. In these patients, PAH was caused by unidentified or hereditary factors (65%) or connective tissue diseases (23%).

Ventavis has not been studied in children younger than 18 years old.

What is the most important information I should know about Ventavis?

Ventavis may not be right for you. Before taking Ventavis, tell your doctor about all of your medical conditions, including if you have liver or kidney problems; are pregnant, or plan to become pregnant; or are breast-feeding. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take medicines used to treat high blood pressure or heart problems or medicines that lessen blood clotting (warfarin, Coumadin, Jantoven). Ventavis and other medicines may affect each other, causing side effects.

What are the possible side effects of Ventavis?

• Ventavis may cause side effects, including feeling dizzy, lightheaded, and faint. If you have any of these side effects, you should stand up slowly when you get out of chairs or bed. Tell your doctor if your fainting gets worse during treatment with Ventavis. Your doctor may need to change your dose or treatment.
• Do not drive a car or operate any tools or machines if dizziness or fainting from low blood pressure is a problem for you.
• You may have trouble breathing after taking Ventavis, because it may cause the muscles around your airway to tighten (bronchospasm). Get emergency help right away if you have trouble breathing.
• The most common side effects of Ventavis include red face (flushing), increased cough, low blood pressure, headaches, nausea, spasm of your jaw muscles that makes it hard to open your mouth, and fainting.

Talk to your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Ventavis. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Please see full Prescribing Information