• Why Take Ventavis?

• Start and Stay on Therapy

•      PAH Pathways

•      Understanding Your Role

•      ABCs: Making the Most of
       Ventavis Treatments

• Ventavis FAQs

• Taking Ventavis with the
  I-neb AAD

• Resources

• For Healthcare
  Professionals

Getting Started on Ventavis Inhalation Solution

Starting you on the right path with Ventavis

PAH Pathways offers patients on Ventavis a clear path to getting started on therapy. Working with your doctor's office, PAH Pathways and your specialty pharmacy make it easier for you to get your medicine when you need it. Here's how it all comes together:

1. Your doctor prescribes Ventavis by completing enrollment forms: The process starts when your doctor's office faxes your Ventavis enrollment form to PAH Pathways.

2. PAH Pathways contacts you: Once we receive your Ventavis enrollment form, PAH Pathways will:

• Contact you to discuss starting Ventavis and answer any questions you may have
• Forward your information to an in-network specialty pharmacy, who will discuss insurance coverage with you, and deliver Ventavis directly and conveniently to your home
• Mail you a Ventavis welcome packet

3. Specialty pharmacy coordinates your insurance coverage: Ventavis is not available in your retail pharmacy; rather, it is carried by a network of specialty pharmacies. Once your information has been sent to a specialty pharmacy, the pharmacy will:

• Obtain insurance approval and determine your benefit status for Ventavis and I-neb AAD System
• Notify you of your out-of-pocket expenses
• Provide information on financial assistance, if needed

4. You receive Ventavis and device training: Your specialty pharmacy ships Ventavis and the I-neb AAD System directly to your home. Your specialty pharmacy also schedules a training session for you so that you can understand how and when to take Ventavis. By using long and slow breaths, many patients have decreased their treatment times. A nurse educator conducts a training session, which can take place at your home or in a location that's convenient for you.

Know that if at any time you have a problem with your I-neb AAD System (for example, your I-neb AAD System is not working), you can call your specialty pharmacy's 24-hour emergency service number.

5. You receive ongoing support: Know that after you've started on therapy, you can contact PAH Pathways with questions or concerns about the delivery of your medicine, insurance coverage, or financial assistance programs if you are eligible.

You can also call PAH Pathways, Monday through Friday, 9 AM-8 PM (ET)/6 AM-5 PM (PT), with questions about any of these steps: 1-866-ACTELION (228-3546).

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What is Ventavis?

Ventavis is a prescription medicine used to treat adults with certain kinds of severe pulmonary arterial hypertension (PAH), a condition in which blood pressure is too high in the blood vessels between the heart and the lungs. Ventavis may improve your ability to exercise and your symptoms for a short time by lowering your blood pressure and opening up the blood vessels in your lungs.

• In the key clinical study, Ventavis showed clinical improvement as defined by 3 specific measurements: ability to exercise as measured by the 6-minute walk test, symptoms (NYHA Functional Class), and decrease in the worsening of PAH symptoms.
• Ventavis is a medication you breathe in through a special device called the I-neb Adaptive Aerosol Delivery (AAD) System.

The study showing Ventavis is effective included mainly patients with NYHA Functional Class III-IV PAH. In these patients, PAH was caused by unidentified or hereditary factors (65%) or connective tissue diseases (23%).

Ventavis has not been studied in children younger than 18 years old.

What is the most important information I should know about Ventavis?

Ventavis may not be right for you. Before taking Ventavis, tell your doctor about all of your medical conditions, including if you have liver or kidney problems; are pregnant, or plan to become pregnant; or are breast-feeding. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take medicines used to treat high blood pressure or heart problems or medicines that lessen blood clotting (warfarin, Coumadin, Jantoven). Ventavis and other medicines may affect each other, causing side effects.

What are the possible side effects of Ventavis?

• Ventavis may cause side effects, including feeling dizzy, lightheaded, and faint. If you have any of these side effects, you should stand up slowly when you get out of chairs or bed. Tell your doctor if your fainting gets worse during treatment with Ventavis. Your doctor may need to change your dose or treatment.
• Do not drive a car or operate any tools or machines if dizziness or fainting from low blood pressure is a problem for you.
• You may have trouble breathing after taking Ventavis, because it may cause the muscles around your airway to tighten (bronchospasm). Get emergency help right away if you have trouble breathing.
• The most common side effects of Ventavis include red face (flushing), increased cough, low blood pressure, headaches, nausea, spasm of your jaw muscles that makes it hard to open your mouth, and fainting.

Talk to your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Ventavis. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Please see full Prescribing Information