• Why Take Ventavis?

• Start and Stay on Therapy

• Ventavis FAQs

• Taking Ventavis with the
  I-neb AAD

•      Ventavis Dosing Options

•      The I-neb is My Neb

•      
  Setting Up the I-neb AAD

• Resources

• For Healthcare
  Professionals

Cleaning the I-neb AAD

To keep your I-neb AAD System in the best working condition, use distilled water to clean it once a day and boil some of the parts weekly.

1. Starting the day¹

Load the blue case with six clean, dry chamber lids with mesh—the blue case is always for clean chamber lids.

Fill the orange case with distilled water and secure the lid—the orange case is now ready to store up to six used chamber lids with mesh.

2. During the day¹

• Remove a chamber lid with mesh from the blue carrying case and place it on top of the I-neb AAD System medication chamber. Close the latch and attach the mouthpiece.
• Take your Ventavis treatment.
• When finished with your treatment, remove the used chamber lid with mesh and place it in the orange carrying case.
• Repeat the steps above each time you take a Ventavis treatment.

3. Ending the day¹

When your orange case is filled with used chamber lids with mesh from the day’s treatments, you’re ready for once-daily cleaning.

Remove the chamber lids with mesh and place them in the wash basket.

Place the mouthpiece, medication chamber, chamber lids, and drug guide in the main wash basket.

Using only one drop of dishwashing liquid,* wash all of the pieces in distilled water.

Rinse the pieces with more distilled water (never reuse the distilled water).

Shake off the water and then air dry the pieces for 2 hours before using again.

Be sure to clean the orange used chamber lid with mesh carrying case with soapy water at least once a week.

Put all parts you clean every day into cleaning basket (do not boil device body).

Only use distilled water to clean your I-neb AAD System

Your I-neb AAD System contains chamber lids with mesh with tiny holes. Ordinary tap or spring water contains minerals. If either of these is used to clean your I-neb AAD System, these minerals may build up and block the tiny holes in the mesh lids. This can lower the flow of the drug to your lungs and increase treatment time. Distilled water will not clog these tiny holes. That is why it is important that you only use distilled water for the daily cleaning and weekly boiling of your I-neb AAD System components and for storing used chamber lids with mesh. It is also very important that you never reuse distilled water.

Weekly Boiling

• Put all of the parts in the cleaning basket.¹
• Boil for 6 to 10 minutes—do not microwave since some of the parts are metal (also, do not wash in the dishwasher as this may damage the parts).
• Rinse with distilled water.
• Shake off the water and then allow to air dry.

A tip: Keep all of your supplies together to make it as easy as possible at treatment and cleaning time.

If you have any questions about the use, care, and cleaning of your I-neb AAD System, just call a PAH Pathways Counselor, toll-free, at 1-866-ACTELION (1- 866-228-3546).

Learn the ABCs—Angle, Breathing, Cleaning—to make the most of your Ventavis treatment.

I-neb AAD System User Guide

Read more about the I-neb AAD system:

What is Ventavis?

Ventavis is a prescription medicine used to treat adults with certain kinds of severe pulmonary arterial hypertension (PAH), a condition in which blood pressure is too high in the blood vessels between the heart and the lungs. Ventavis may improve your ability to exercise and your symptoms for a short time by lowering your blood pressure and opening up the blood vessels in your lungs.

• In the key clinical study, Ventavis showed clinical improvement as defined by 3 specific measurements: ability to exercise as measured by the 6-minute walk test, symptoms (NYHA Functional Class), and decrease in the worsening of PAH symptoms.
• Ventavis is a medication you breathe in through a special device called the I-neb Adaptive Aerosol Delivery (AAD) System.

The study showing Ventavis is effective included mainly patients with NYHA Functional Class III-IV PAH. In these patients, PAH was caused by unidentified or hereditary factors (65%) or connective tissue diseases (23%).

Ventavis has not been studied in children younger than 18 years old.

What is the most important information I should know about Ventavis?

Ventavis may not be right for you. Before taking Ventavis, tell your doctor about all of your medical conditions, including if you have liver or kidney problems; are pregnant, or plan to become pregnant; or are breast-feeding. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take medicines used to treat high blood pressure or heart problems or medicines that lessen blood clotting (warfarin, Coumadin, Jantoven). Ventavis and other medicines may affect each other, causing side effects.

What are the possible side effects of Ventavis?

• Ventavis may cause side effects, including feeling dizzy, lightheaded, and faint. If you have any of these side effects, you should stand up slowly when you get out of chairs or bed. Tell your doctor if your fainting gets worse during treatment with Ventavis. Your doctor may need to change your dose or treatment.
• Do not drive a car or operate any tools or machines if dizziness or fainting from low blood pressure is a problem for you.
• You may have trouble breathing after taking Ventavis, because it may cause the muscles around your airway to tighten (bronchospasm). Get emergency help right away if you have trouble breathing.
• The most common side effects of Ventavis include red face (flushing), increased cough, low blood pressure, headaches, nausea, spasm of your jaw muscles that makes it hard to open your mouth, and fainting.

Talk to your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Ventavis. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Please see full Prescribing Information